Presented at AACR SL in Montreal, Canada. Updated for Synthetic Lethality Approaches in Oncology Gordon Research Conference in Portland, Maine on July 20, 2025.
This poster showcases how Deep Origin is using large-scale cellular simulations to uncover novel synthetic lethal pairs and conditional biomarkers.
By leveraging our proprietary OncoSim toolkit, which combines mechanistic and machine learning models across over 1,000 oncology cell lines, we screen millions of gene combinations in silico to identify promising therapeutic targets.
Our approach has already predicted over 100 novel synthetic lethal pairs, with some validated experimentally, and has the potential to stratify patients, predict resistance mutations, and guide drug prioritization.
We are actively seeking partners interested in collaborating on our platform or co-developing high-impact synthetic lethality targets.